Q3 2025 Hedge Fund Analysis

Summary

• Hedge fund holdings can help you discover new investment ideas

• We identified & follow the top biopharma-focused hedge funds

• Q3 hedge fund holdings reports were released on ~11/14/25

• This report focuses on top holdings of top biopharma hedge funds as of 09/30/25

Top Biopharma Hedge Funds

At BPIQ we identified the top smid-cap biopharma-focused hedge funds ^1. We updated our database of holding and other info re: these funds with their recently-released data for holdings as of 09/30/25 ^2 (See table 1 📸)

If you click the Hedge Fund link in our new app.bpiq.com site you can search for any ticker to instantly find whether any of these funds held that ticker at the end of last quarter. If you are a BPIQ subscriber you will see results instantly from the latest holdings release of all the hedge funds of Table 1.

Table 1. General Info Re: Top Biopharma-focused Hedge Funds^1

*The Fund Q to Q change is based on the value of stock holdings, not the overall value and return of the fund, which is not possible based on public information.

Top Holdings

From our tracking and back-testing, we have found that top and consensus holdings of these funds consistently outperform XBI (See Table 2). We recently obtained similar results when we updated our backtesting through 13F holdings data thru Q4 of 2024.

Table 2. Results of back-testing various strategies (1-6) based on consensus and/or top holdings across the top biopharma hedge funds.

Accordingly, we identified the top 20 holdings in their most recent quarterly report for these biopharma hedge funds to find which tickers are top holdings of multiple biotech hedge funds (Table 3 📸). See Table 4 for the Top 20s of a few major hedge funds among the 36 we analyzed. 📸

Table 3. Top occurrences of companies in the Top 20 of Hedge Funds*

*Sign up for an Elite plan to get access to all our hedge fund data and analysis, including the top 13 tickers above.

Table 4. Top 20 stock positions held by biotech hedge funds in Q3 2025 ^3

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Footnotes:

^1 Hedge funds and other SEC form 13F filing entities

^2 Like all hedge funds, updated holdings info for the top biopharma hedge funds as of the last day of last quarter, were due 45 days after the end of the quarter.

^3 Table 4 is color-coded based on the prevalence of the ticker in the hedge funds Top 20s. Darker green colored cells have the highest occurrence (with the darkest green showing 12 occurrences) and lighter green colored cells have less occurrences (with the lightest green showing 5 occurrences). Refer to Table 3 to see specific numbers of occurrences for each ticker.

This article is not investment, tax, or legal advice. Please do your own diligence and seek advice from professional advisors representing your interests.

Article history:

First published 11/27/25 EJV/AV/DG